"Search and Destroy" is a song originally recorded by The Stooges in 1973 and re-recorded in 2005. The song appears on the band's third studio album, Raw Power. Lead singer Iggy Pop said that he pulled the title "from a column heading in a Time Magazine article about the Vietnam War." It has been covered by numerous artists, including Cursed, Def Leppard, Red Hot Chili Peppers, EMF, the Sex Pistols, Sid Vicious, The Flowers of Romance, Samiam, The Dead Boys, Rocket From The Tombs, The Dictators, Shotgun Messiah, Verdena and Emanuel.

The song also provided the title of an influential late 1970s punk magazine based out of San Francisco.

In 1997, "Search and Destroy" along with the rest of the songs on Raw Power were remixed and remastered by Iggy Pop and Bruce Dickinson. The result was far more aggressive and stripped down than the original release, which had been mixed by David Bowie.

Henry Rollins has a large tattoo on his back of an image with large text reading "SEARCH & DESTROY."

This song was featured in the video games True Crime: New York City, Tony Hawk's American Sk8land, Tony Hawk's American Wasteland, and Guitar Hero II, as well as in the Wes Anderson film The Life Aquatic with Steve Zissou, the Cameron Crowe film Almost Famous and Bam Margera's Haggard: The Movie.

In the skateboard video Photosynthesis by Alien Workshop, Anthony Van Engelen used this song during his part. Ragdoll, another skateboarder, also used this song in Pig Wood's Slaughterhouse.

In 2004, Rolling Stone ranked it #468 on their list of the 500 Greatest Songs of All Time.