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Piedmont Airlines was a regional airline based in Winston-Salem, North Carolina; the airline began operations in 1948. In 1989, the airline was purchased and integrated into US Air. At its peak, its route system stretched from Wilmington, N.C., northwest to Cincinnati, Ohio, with numerous intermediate stops. Early routes were operated with Douglas DC-3 aircraft. The airline was based at Smith Reynolds Airport in Winston-Salem, North Carolina.
As Piedmont grew over the years, their route system primarily served the U.S. states of North Carolina, South Carolina, Virginia and West Virginia. However, by the end of 1978, and while still under U.S. route regulation, Piedmont had grown to include an area stretching northward to New York City, New York, and westward as far as Denver, Colorado, and southward to Miami, Florida.






