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Lapatinib (Wikipedia.org)

Lapatinib (INN) or lapatinib ditosylate (USAN), also known as GW572016, is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine (Xeloda TM). It is marketed by GSK in the U.S. as Tykerb. Once regulatory approval has been granted, it will be marketed as Tyverb in Europe.

Lapatinib is a once-daily oral drug indicated for women who have received prior treatment with the intravenous drug trastuzumab (Herceptin TM) and cancer drugs called taxanes and anthracyclines. blank">http://newsmax.com/archives/articles/2007/3/13/155445.shtml

Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and _HER2/neu (ErbB-2) dual tyrosine kinase inhibitor. It inhibits receptor autophosphorylation and activation by binding to the ATP-binding pocket of the EGFR/HER2 protein kinase domain.

In patients with HER2/neu positive metastatic breast cancer that has progressed following treatment with previous chemotherapy regimens that included an anthracycline, a taxane, and trastuzumab, randomized clinical trial has demonstrated that the addition of lapatinib to capecitabine delayed the time of further cancer growth compared to capecitabine alone.http://content.nejm.org/cgi/content/abstract/355/26/2733

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Jean-Pierre Garnier, chief executive officer of GlaxoSmithKline Plc, talks with Bloomberg's Francine Lacqua from London about first-quarter earnings, the company's drugs Avandia, Tykerb and Cervarix, ...
8 months ago
Bloomberg - Financial News
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Cancer Skin Care for Side Effects of Chemotherapy and Radiation Therapy, like Tarceva, Tykerb, Erbitux and other rash causing treatments
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2 years ago
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A new drug called Tykerb shows great promise to patients suffering from head and neck cancer, with Jean-pierre Garnier, GlaxoSmithKline CEO and CNBCs Maria Bartiromo
a year ago
MSN Video
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