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Lamotrigine
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Wikipedia.org
Lamotrigine (Wikipedia.org)

Lamotrigine (marketed as Lamictal ( ) by GlaxoSmithKline, called Lamictin in South Africa, למוג'ין (Lamogine) in Israel, and 라믹탈 in South Korea) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. Some think that it is a Na + channel blocker. It is inactivated by hepatic glucuronidation.

Lamotrigine has been successful in controlling rapid cycling and mixed bipolar states in people who have not received adequate relief from lithium, carbamazepine and/or valproate, possibly having significantly more antidepressant potency than either carbamazepine or valproate. It is useful as part of the treatment of some people with major (unipolar) depression, and has recently been reported to be a useful treatment for some people with post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD). A recent study reported benefeficial effects on individuals with schizoaffective disorder, bipolar subtype with depression.(Source: Lamotragine FAQ.)

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A pharmacist explains how Lamictal works, why doctors prescribe this anticonvulsant, and common side effects of the drug.
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a year ago
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2 years ago
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Depression: Lifting the Dark Veil is a ground-breaking book that discusses a new approach to depression and bipolar disorder. The book discusses the use of safe, non-addictive medications that have ...
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5 months ago
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U.S. Food and Drug Administration
FDA is alerting health care professionals and patients that infants exposed to Lamictal (lamotrigine) during the first trimester of pregnancy may have an increased risk of being born with a cleft lip ...
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a year ago
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